Molecular Switch Role of Akt in Polygonatum odoratum Lectin-Induced Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer A549 Cells

Chunyang Li; Jie Chen; Bangmin Lu; Zheng Shi; Hailian Wang; Bin Zhang; Kailiang Zhao; Wei Qi; Jinku Bao; Yi Wang

doi:10.1371/journal.pone.0101526

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Open Access

Peer-reviewed

Research Article

Molecular Switch Role of Akt in Polygonatum odoratum Lectin-Induced Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer A549 Cells

Chunyang Li ,

Contributed equally to this work with: Chunyang Li, Jie Chen, Bangmin Lu

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Jie Chen ,

Contributed equally to this work with: Chunyang Li, Jie Chen, Bangmin Lu

Affiliation Central Laboratory of Clinical Medicine, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, China
⨯
Bangmin Lu ,

Contributed equally to this work with: Chunyang Li, Jie Chen, Bangmin Lu

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Zheng Shi,

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Hailian Wang,

Affiliations School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China, Institute of Organ Transplantation, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, China
⨯
Bin Zhang,

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Kailiang Zhao,

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Wei Qi,

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Jinku Bao ,

* E-mail: jinkubao@yahoo.com (JB); Yi.Wang@nationwidechildrens.org (YW)

Affiliation School of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China
⨯
Yi Wang

* E-mail: jinkubao@yahoo.com (JB); Yi.Wang@nationwidechildrens.org (YW)

Affiliations Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, China, Center for Perinatal Research, Nationwide Children’s Hospital, Columbus, Ohio, United States of America
⨯

Molecular Switch Role of Akt in Polygonatum odoratum Lectin-Induced Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer A549 Cells

Chunyang Li,
Jie Chen,
Bangmin Lu,
Zheng Shi,
Hailian Wang,
Bin Zhang,
Kailiang Zhao,
Wei Qi,
Jinku Bao,
Yi Wang

Published: July 3, 2014
https://doi.org/10.1371/journal.pone.0101526

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Apoptosis
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Autophagic cell death
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Lectins
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Small interfering RNA
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Non-small cell lung cancer
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