TRIM68 Negatively Regulates IFN-β Production by Degrading TRK Fused Gene, a Novel Driver of IFN-β Downstream of Anti-Viral Detection Systems

• Claire Wynne,

  Affiliations Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, School of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland

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• Elisa Lazzari,

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Siobhán Smith,

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Eoghan M. McCarthy,

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Joan Ní Gabhann,

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Lara E. Kallal,

  Affiliation Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, United States of America

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• Rowan Higgs,

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Sally Ann Cryan,

  Affiliations School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland

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• Christine A. Biron,

  Affiliation Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, United States of America

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• Caroline A. Jefferies

  * E-mail: cjefferies@rcsi.ie

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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