Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

Zhe Chang; Huaiqiang Ju; Jianhua Ling; Zhuonan Zhuang; Zhongkui Li; Huamin Wang; Jason B. Fleming; James W. Freeman; Dihua Yu; Peng Huang; Paul J. Chiao

doi:10.1371/journal.pone.0101452

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Open Access

Peer-reviewed

Research Article

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

Zhe Chang ,

Contributed equally to this work with: Zhe Chang, Huaiqiang Ju

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Huaiqiang Ju ,

Contributed equally to this work with: Zhe Chang, Huaiqiang Ju

Affiliations Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Jianhua Ling,

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zhuonan Zhuang,

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zhongkui Li,

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Huamin Wang,

Affiliation Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jason B. Fleming,

Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
James W. Freeman,

Affiliation The Division of Hematology and Medical Oncology, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Dihua Yu,

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Peng Huang,

Affiliation Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
⨯
Paul J. Chiao

* E-mail: pjchiao@mdanderson.org

Affiliation Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

Zhe Chang,
Huaiqiang Ju,
Jianhua Ling,
Zhuonan Zhuang,
Zhongkui Li,
Huamin Wang,
Jason B. Fleming,
James W. Freeman,
Dihua Yu,
Peng Huang

Published: July 16, 2014
https://doi.org/10.1371/journal.pone.0101452

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