Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3′-Deoxy-3′-[18F]-Fluorothymidine Cellular Retention

Open Access

Peer-reviewed

Research Article

Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3′-Deoxy-3′-[¹⁸F]-Fluorothymidine Cellular Retention

Roberta Sala,

Affiliation Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Quang-Dé Nguyen,

Affiliation Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Chirag B. K. Patel,

Affiliation Institute of Chemical Biology, Department of Chemistry, Imperial College London, London, United Kingdom
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David Mann,

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
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Joachim H. G. Steinke,

Affiliation Institute of Chemical Biology, Department of Chemistry, Imperial College London, London, United Kingdom
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Ramon Vilar,

Affiliation Institute of Chemical Biology, Department of Chemistry, Imperial College London, London, United Kingdom
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Eric O. Aboagye

* E-mail: eric.aboagye@imperial.ac.uk

Affiliation Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Phosphorylation
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Cell cycle and cell division
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Transfection
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Protein expression
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Synthesis phase
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Thymidines
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Mitosis
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Small interfering RNA
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