Hesperidin Induces Paraptosis Like Cell Death in Hepatoblatoma, HepG2 Cells: Involvement of ERK1/2 MAPK

Silvia Yumnam; Hyeon Soo Park; Mun Ki Kim; Arulkumar Nagappan; Gyeong Eun Hong; Ho Jeong Lee; Won Sup Lee; Eun Hee Kim; Jae Hyeon Cho; Sung Chul Shin; Gon Sup Kim

doi:10.1371/journal.pone.0101321

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Open Access

Peer-reviewed

Research Article

Hesperidin Induces Paraptosis Like Cell Death in Hepatoblatoma, HepG2 Cells: Involvement of ERK1/2 MAPK

Silvia Yumnam,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Hyeon Soo Park,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Mun Ki Kim,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Arulkumar Nagappan,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Gyeong Eun Hong,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Ho Jeong Lee,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Won Sup Lee,

Affiliation Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University Hospital, Jinju, Republic of Korea
⨯
Eun Hee Kim,

Affiliation Department of Nursing Science, International University of Korea, Jinju, Republic of Korea
⨯
Jae Hyeon Cho,

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯
Sung Chul Shin,

Affiliation Department of Chemistry, Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea
⨯
Gon Sup Kim

* E-mail: gonskim@gnu.ac.kr

Affiliation Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju, Republic of Korea
⨯

Hesperidin Induces Paraptosis Like Cell Death in Hepatoblatoma, HepG2 Cells: Involvement of ERK1/2 MAPK

Silvia Yumnam,
Hyeon Soo Park,
Mun Ki Kim,
Arulkumar Nagappan,
Gyeong Eun Hong,
Ho Jeong Lee,
Won Sup Lee,
Eun Hee Kim,
Jae Hyeon Cho,
Sung Chul Shin

Published: June 30, 2014
https://doi.org/10.1371/journal.pone.0101321

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Apoptosis
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Hepatocellular carcinoma
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Autophagic cell death
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Cell death
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Chromatin
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DNA fragmentation
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Condensation
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