Genotyping Cancer-Associated Genes in Chordoma Identifies Mutations in Oncogenes and Areas of Chromosomal Loss Involving CDKN2A, PTEN, and SMARCB1

Edwin Choy; Laura E. MacConaill; Gregory M. Cote; Long P. Le; Jacson K. Shen; Gunnlaugur P. Nielsen; Anthony J. Iafrate; Levi A. Garraway; Francis J. Hornicek; Zhenfeng Duan

doi:10.1371/journal.pone.0101283

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Open Access

Peer-reviewed

Research Article

Genotyping Cancer-Associated Genes in Chordoma Identifies Mutations in Oncogenes and Areas of Chromosomal Loss Involving CDKN2A, PTEN, and SMARCB1

Edwin Choy ,

* E-mail: echoy@partners.org

Affiliations Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Laura E. MacConaill,

Affiliation Center for Cancer Genome Discovery and Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
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Gregory M. Cote,

Affiliations Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Long P. Le,

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jacson K. Shen,

Affiliation Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Gunnlaugur P. Nielsen,

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Anthony J. Iafrate,

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Levi A. Garraway,

Affiliation Center for Cancer Genome Discovery and Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Francis J. Hornicek,

Affiliation Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Zhenfeng Duan

Affiliation Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯

Genotyping Cancer-Associated Genes in Chordoma Identifies Mutations in Oncogenes and Areas of Chromosomal Loss Involving CDKN2A, PTEN, and SMARCB1

Edwin Choy,
Laura E. MacConaill,
Gregory M. Cote,
Long P. Le,
Jacson K. Shen,
Gunnlaugur P. Nielsen,
Anthony J. Iafrate,
Levi A. Garraway,
Francis J. Hornicek,
Zhenfeng Duan

Published: July 1, 2014
https://doi.org/10.1371/journal.pone.0101283

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