Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice

Robin L. P. Jump; Alex Polinkovsky; Kelly Hurless; Brett Sitzlar; Kevin Eckart; Myreen Tomas; Abhishek Deshpande; Michelle M. Nerandzic; Curtis J. Donskey

doi:10.1371/journal.pone.0101267

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Peer-reviewed

Research Article

Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice

Robin L. P. Jump ,

* E-mail: robinjump@gmail.com

Affiliations Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Alex Polinkovsky,

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
⨯
Kelly Hurless,

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
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Brett Sitzlar,

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
⨯
Kevin Eckart,

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
⨯
Myreen Tomas,

Affiliation Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Abhishek Deshpande,

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
⨯
Michelle M. Nerandzic,

Affiliation Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
⨯
Curtis J. Donskey

Affiliations Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
⨯

Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice

Robin L. P. Jump,
Alex Polinkovsky,
Kelly Hurless,
Brett Sitzlar,
Kevin Eckart,
Myreen Tomas,
Abhishek Deshpande,
Michelle M. Nerandzic,
Curtis J. Donskey

Published: July 2, 2014
https://doi.org/10.1371/journal.pone.0101267

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