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Open Access
Peer-reviewed
Research Article
A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection
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Krystal Cole ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliations Office of Educational Programs, Brookhaven National Laboratory, Upton, New York, United States of America, Purchase College, State University of New York, Purchase, New York, United States of America
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Christian G. Roessler ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliation Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York, United States of America
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Elizabeth A. Mulé ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliations Office of Educational Programs, Brookhaven National Laboratory, Upton, New York, United States of America, Freeport High School, Freeport, New York, United States of America
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Emma J. Benson-Xu ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliations Office of Educational Programs, Brookhaven National Laboratory, Upton, New York, United States of America, Georgetown Day School, Washington, DC, United States of America
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Jeffrey D. Mullen ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliations Office of Educational Programs, Brookhaven National Laboratory, Upton, New York, United States of America, Physics Department, University of Oregon, Eugene, Oregon, United States of America
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Benjamin A. Le ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliations Office of Educational Programs, Brookhaven National Laboratory, Upton, New York, United States of America, Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America
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Alanna M. Tieman ,
Contributed equally to this work with: Krystal Cole, Christian G. Roessler, Elizabeth A. Mulé, Emma J. Benson-Xu, Jeffrey D. Mullen, Benjamin A. Le, Alanna M. Tieman
Affiliations Office of Educational Programs, Brookhaven National Laboratory, Upton, New York, United States of America, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
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Claire Birone,
Affiliation Babylon Junior-Senior High School, Babylon, New York, United States of America
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Maria Brown,
Affiliation Sayville High School, West Sayville, New York, United States of America
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Jesus Hernandez,
Affiliation Queens Metropolitan High School, Forest Hills, New York, United States of America
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Sherry Neff,
Affiliation Shoreham-Wading River High School, Shoreham, New York, United States of America
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Daniel Williams,
Affiliation Shelter Island High School, Shelter Island, New York, United States of America
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Marc Allaire,
Affiliation Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York, United States of America
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Allen M. Orville,
Affiliations Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York, United States of America, Biosciences Department, Brookhaven National Laboratory, Upton, New York, United States of America
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Robert M. Sweet,
Affiliations Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York, United States of America, Biosciences Department, Brookhaven National Laboratory, Upton, New York, United States of America
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Alexei S. Soares
* E-mail: soares@bnl.gov
Affiliation Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York, United States of America
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A Linear Relationship between Crystal Size and Fragment Binding Time Observed Crystallographically: Implications for Fragment Library Screening Using Acoustic Droplet Ejection
- Krystal Cole,
- Christian G. Roessler,
- Elizabeth A. Mulé,
- Emma J. Benson-Xu,
- Jeffrey D. Mullen,
- Benjamin A. Le,
- Alanna M. Tieman,
- Claire Birone,
- Maria Brown,
- Jesus Hernandez
- Published: July 2, 2014
- https://doi.org/10.1371/journal.pone.0101036