Reversal of Muscle Atrophy by Zhimu-Huangbai Herb-Pair via Akt/mTOR/FoxO3 Signal Pathway in Streptozotocin-Induced Diabetic Mice

Jinbao Zhang; Pengwei Zhuang; Yan Wang; Lili Song; Mixia Zhang; Zhiqiang Lu; Lu Zhang; Jing Wang; Paulos N. Alemu; Yanjun Zhang; Hongjun Wei; Hongyan Li

doi:10.1371/journal.pone.0100918

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Open Access

Peer-reviewed

Research Article

Reversal of Muscle Atrophy by Zhimu-Huangbai Herb-Pair via Akt/mTOR/FoxO3 Signal Pathway in Streptozotocin-Induced Diabetic Mice

Jinbao Zhang ,

Contributed equally to this work with: Jinbao Zhang, Pengwei Zhuang

Affiliation Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Pengwei Zhuang ,

Contributed equally to this work with: Jinbao Zhang, Pengwei Zhuang

Affiliations Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Tianjin JF-Pharmaland Technology Development Co., Ltd., Tianjin, China
⨯
Yan Wang,

Affiliations Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Lili Song,

Affiliations Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Mixia Zhang,

Affiliations Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Zhiqiang Lu,

Affiliation Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Lu Zhang,

Affiliation Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Jing Wang,

Affiliation Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Paulos N. Alemu,

Affiliation Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Yanjun Zhang ,

* E-mail: zyjsunye@163.com

Affiliations Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Hongjun Wei,

Affiliation Tianjin JF-Pharmaland Technology Development Co., Ltd., Tianjin, China
⨯
Hongyan Li

Affiliation Tianjin JF-Pharmaland Technology Development Co., Ltd., Tianjin, China
⨯

Reversal of Muscle Atrophy by Zhimu-Huangbai Herb-Pair via Akt/mTOR/FoxO3 Signal Pathway in Streptozotocin-Induced Diabetic Mice

Jinbao Zhang,
Pengwei Zhuang,
Yan Wang,
Lili Song,
Mixia Zhang,
Zhiqiang Lu,
Lu Zhang,
Jing Wang,
Paulos N. Alemu,
Yanjun Zhang

Published: June 26, 2014
https://doi.org/10.1371/journal.pone.0100918

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Skeletal muscles
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Atrophy
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Insulin
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