A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

Nuruddeen D. Lewis; Lori A. Patnaude; Josephine Pelletier; Donald J. Souza; Susan M. Lukas; F. James King; Jonathan D. Hill; Dimitria E. Stefanopoulos; Kelli Ryan; Sudha Desai; Donna Skow; Stefan G. Kauschke; Andre Broermann; Daniel Kuzmich; Christian Harcken; Eugene R. Hickey; Louise K. Modis

doi:10.1371/journal.pone.0100883

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Research Article

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

Nuruddeen D. Lewis,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Lori A. Patnaude,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Josephine Pelletier,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Donald J. Souza,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Susan M. Lukas,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
F. James King,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Jonathan D. Hill,

Affiliation Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Dimitria E. Stefanopoulos,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Kelli Ryan,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Sudha Desai,

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Donna Skow,

Affiliation Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Stefan G. Kauschke,

Affiliation CardioMetabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Biberach, Germany
⨯
Andre Broermann,

Affiliation CardioMetabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Biberach, Germany
⨯
Daniel Kuzmich,

Affiliation Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Christian Harcken,

Affiliation Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
Eugene R. Hickey,

Affiliation Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
[ ... ],
Louise K. Modis

* E-mail: Louise-kelly.modis@boehringer-ingelheim.com

Affiliation Departments of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgebury, Connecticut, United States of America
⨯
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A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

Nuruddeen D. Lewis,
Lori A. Patnaude,
Josephine Pelletier,
Donald J. Souza,
Susan M. Lukas,
F. James King,
Jonathan D. Hill,
Dimitria E. Stefanopoulos,
Kelli Ryan,
Sudha Desai

Published: June 26, 2014
https://doi.org/10.1371/journal.pone.0100883

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