Integrated Analysis of Mutation Data from Various Sources Identifies Key Genes and Signaling Pathways in Hepatocellular Carcinoma

Yuannv Zhang; Zhaoping Qiu; Lin Wei; Ruqi Tang; Baofeng Lian; Yingjun Zhao; Xianghuo He; Lu Xie

doi:10.1371/journal.pone.0100854

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Open Access

Peer-reviewed

Research Article

Integrated Analysis of Mutation Data from Various Sources Identifies Key Genes and Signaling Pathways in Hepatocellular Carcinoma

Yuannv Zhang ,

Contributed equally to this work with: Yuannv Zhang, Zhaoping Qiu

Affiliation State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Zhaoping Qiu ,

Contributed equally to this work with: Yuannv Zhang, Zhaoping Qiu

Affiliation State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Lin Wei,

Affiliation State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Ruqi Tang,

Affiliation State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Baofeng Lian,

Affiliation Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, China
⨯
Yingjun Zhao,

Affiliation State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Xianghuo He ,

* E-mail: xhhe@shsci.org (XH); xielu@scbit.org (LX)

Affiliation State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Lu Xie

* E-mail: xhhe@shsci.org (XH); xielu@scbit.org (LX)

Affiliation Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, China
⨯

Integrated Analysis of Mutation Data from Various Sources Identifies Key Genes and Signaling Pathways in Hepatocellular Carcinoma

Yuannv Zhang,
Zhaoping Qiu,
Lin Wei,
Ruqi Tang,
Baofeng Lian,
Yingjun Zhao,
Xianghuo He,
Lu Xie

Published: July 2, 2014
https://doi.org/10.1371/journal.pone.0100854

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Hepatocellular carcinoma
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Mutation detection
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Cancers and neoplasms
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Mutation databases
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Point mutation
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Nonsense mutation
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Genetic networks
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