Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells

Ying-Ying Liang; Ming-Yuan Chen; Yi-Jun Hua; Shi Chen; Li-Sheng Zheng; Xue Cao; Li-Xia Peng; Ping Xie; Bi-Jun Huang; Rui Sun; Lin Wang; Yan-Qun Xiang; Xiang Guo; Chao-Nan Qian

doi:10.1371/journal.pone.0100843

Loading metrics

Open Access

Peer-reviewed

Research Article

Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells

Ying-Ying Liang,

Affiliation State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Ming-Yuan Chen,

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Yi-Jun Hua,

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Shi Chen,

Affiliation Department of Gastroesophageal surgery, The Sixth Affliated Hospital (Gastrointestinal and Anal Hospital), Sun Yat-sen University, GuangZhou, China
⨯
Li-Sheng Zheng,

Affiliation State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Xue Cao,

Affiliation State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Li-Xia Peng,

Affiliation State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Ping Xie,

Affiliation State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Bi-Jun Huang,

Affiliation State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Rui Sun,

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Lin Wang,

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Yan-Qun Xiang,

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Xiang Guo,

Affiliation Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯
Chao-Nan Qian

* E-mail: qianchn@sysucc.org.cn

Affiliations State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
⨯

Downregulation of Ras Association Domain Family Member 6 (RASSF6) Underlies the Treatment Resistance of Highly Metastatic Nasopharyngeal Carcinoma Cells

Ying-Ying Liang,
Ming-Yuan Chen,
Yi-Jun Hua,
Shi Chen,
Li-Sheng Zheng,
Xue Cao,
Li-Xia Peng,
Ping Xie,
Bi-Jun Huang,
Rui Sun

Published: July 16, 2014
https://doi.org/10.1371/journal.pone.0100843

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Radiation therapy
Is the Subject Area "Radiation therapy" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Nasopharyngeal carcinoma
Is the Subject Area "Nasopharyngeal carcinoma" applicable to this article?

Thanks for your feedback.
Infrared radiation
Is the Subject Area "Infrared radiation" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
c-Jun N-terminal kinase signaling cascade
Is the Subject Area "c-Jun N-terminal kinase signaling cascade" applicable to this article?

Thanks for your feedback.