Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

Naoto Terami; Daisuke Ogawa; Hiromi Tachibana; Takashi Hatanaka; Jun Wada; Atsuko Nakatsuka; Jun Eguchi; Chikage Sato Horiguchi; Naoko Nishii; Hiroshi Yamada; Kohji Takei; Hirofumi Makino

doi:10.1371/journal.pone.0100777

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Open Access

Peer-reviewed

Research Article

Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

Naoto Terami,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Daisuke Ogawa ,

* E-mail: daiogawa@md.okayama-u.ac.jp

Affiliations Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Diabetic Nephropathy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiromi Tachibana,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Takashi Hatanaka,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Jun Wada,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Atsuko Nakatsuka,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Jun Eguchi,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Chikage Sato Horiguchi,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Naoko Nishii,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroshi Yamada,

Affiliation Department of Neurochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Kohji Takei,

Affiliation Department of Neurochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hirofumi Makino

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

Naoto Terami,
Daisuke Ogawa,
Hiromi Tachibana,
Takashi Hatanaka,
Jun Wada,
Atsuko Nakatsuka,
Jun Eguchi,
Chikage Sato Horiguchi,
Naoko Nishii,
Hiroshi Yamada

Published: June 24, 2014
https://doi.org/10.1371/journal.pone.0100777

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