Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

Jasmin F. Sydow; Florian Lipsmeier; Vincent Larraillet; Maximiliane Hilger; Bjoern Mautz; Michael Mølhøj; Jan Kuentzer; Stefan Klostermann; Juergen Schoch; Hans R. Voelger; Joerg T. Regula; Patrick Cramer; Apollon Papadimitriou; Hubert Kettenberger

doi:10.1371/journal.pone.0100736

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Open Access

Peer-reviewed

Research Article

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

Jasmin F. Sydow,

Current address: Novo Nordisk A/S, Biopharmaceutical Research Unit, Department of Protein Characterisation, Måløv, Denmark

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Florian Lipsmeier,

Affiliation Therapeutics Modalities Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Vincent Larraillet,

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Maximiliane Hilger,

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Bjoern Mautz,

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Michael Mølhøj,

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Jan Kuentzer,

Affiliation Disease & Translational Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Stefan Klostermann,

Affiliation Therapeutics Modalities Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Juergen Schoch,

Affiliation Therapeutics Modalities Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Hans R. Voelger,

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Joerg T. Regula,

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Patrick Cramer,

Affiliation Gene Center Munich and Department of Biochemistry, Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität (LMU), Munich, Germany
⨯
Apollon Papadimitriou,

Affiliation Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯
Hubert Kettenberger

* E-mail: hubert.kettenberger@roche.com

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany
⨯

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

Jasmin F. Sydow,
Florian Lipsmeier,
Vincent Larraillet,
Maximiliane Hilger,
Bjoern Mautz,
Michael Mølhøj,
Jan Kuentzer,
Stefan Klostermann,
Juergen Schoch,
Hans R. Voelger

Published: June 24, 2014
https://doi.org/10.1371/journal.pone.0100736

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