Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

Jeffrey A. Mayfield; Zhong Liang; Garima Agrahari; Shaun W. Lee; Deborah L. Donahue; Victoria A. Ploplis; Francis J. Castellino

doi:10.1371/journal.pone.0100698

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Peer-reviewed

Research Article

Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

Jeffrey A. Mayfield,

Affiliation W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Zhong Liang,

Affiliations W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Garima Agrahari,

Affiliations W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Shaun W. Lee,

Affiliations W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Deborah L. Donahue,

Affiliation W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Victoria A. Ploplis,

Affiliations W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯
Francis J. Castellino

* E-mail: fcastell@nd.edu

Affiliations W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, United States of America, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America
⨯

Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

Jeffrey A. Mayfield,
Zhong Liang,
Garima Agrahari,
Shaun W. Lee,
Deborah L. Donahue,
Victoria A. Ploplis,
Francis J. Castellino

Published: June 26, 2014
https://doi.org/10.1371/journal.pone.0100698

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