Isoaspartyl Formation in Creatine Kinase B Is Associated with Loss of Enzymatic Activity; Implications for the Linkage of Isoaspartate Accumulation and Neurological Dysfunction in the PIMT Knockout Mouse

Open Access

Peer-reviewed

Research Article

Aleksandra Dimitrijevic,

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America
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Zhenxia Qin,

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America
⨯
Dana W. Aswad

* E-mail: dwaswad@uci.edu

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America
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Creatine
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Mouse models
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DNA repair
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Methylation
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Oxidation
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Brain damage
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Central nervous system
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Epileptic seizures
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