Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo

Daisuke Takeda; Takumi Hasegawa; Takeshi Ueha; Yusuke Imai; Akiko Sakakibara; Masaya Minoda; Teruya Kawamoto; Tsutomu Minamikawa; Yasuyuki Shibuya; Toshihiro Akisue; Yoshitada Sakai; Masahiro Kurosaka; Takahide Komori

doi:10.1371/journal.pone.0100530

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Peer-reviewed

Research Article

Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo

Daisuke Takeda,

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Takumi Hasegawa ,

* E-mail: hasetaku@med.kobe-u.ac.jp

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Takeshi Ueha,

Affiliation NeoChemir, Kobe, Japan
⨯
Yusuke Imai,

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Akiko Sakakibara,

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Masaya Minoda,

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Teruya Kawamoto,

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Tsutomu Minamikawa,

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Yasuyuki Shibuya,

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Toshihiro Akisue,

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Yoshitada Sakai,

Affiliation Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Masahiro Kurosaka,

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Takahide Komori

Affiliation Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯

Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo

Daisuke Takeda,
Takumi Hasegawa,
Takeshi Ueha,
Yusuke Imai,
Akiko Sakakibara,
Masaya Minoda,
Teruya Kawamoto,
Tsutomu Minamikawa,
Yasuyuki Shibuya,
Toshihiro Akisue

Published: July 2, 2014
https://doi.org/10.1371/journal.pone.0100530

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Metastasis
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Lung and intrathoracic tumors
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Carbon dioxide
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Apoptosis
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