Loss of Somatostatin Receptor Subtype 2 in Prostate Cancer Is Linked to an Aggressive Cancer Phenotype, High Tumor Cell Proliferation and Predicts Early Metastatic and Biochemical Relapse

Jan K. Hennigs; Julia Müller; Matti Adam; Joshua M. Spin; Emilia Riedel; Markus Graefen; Carsten Bokemeyer; Guido Sauter; Hartwig Huland; Thorsten Schlomm; Sarah Minner

doi:10.1371/journal.pone.0100469

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Open Access

Peer-reviewed

Research Article

Loss of Somatostatin Receptor Subtype 2 in Prostate Cancer Is Linked to an Aggressive Cancer Phenotype, High Tumor Cell Proliferation and Predicts Early Metastatic and Biochemical Relapse

Jan K. Hennigs ,

* E-mail: j.hennigs@uke.de

Affiliations Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Department of Internal Medicine II - Oncology, Hematology, BMT with Section Pneumology, Hubertus-Wald-Tumorzentrum/University Cancer Center Hamburg (UCCH) University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Julia Müller,

Affiliation Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Matti Adam,

Affiliation Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University – School of Medicine, Stanford, California, United States of America
⨯
Joshua M. Spin,

Affiliation Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University – School of Medicine, Stanford, California, United States of America
⨯
Emilia Riedel,

Affiliation Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Markus Graefen,

Affiliation Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Carsten Bokemeyer,

Affiliation Department of Internal Medicine II - Oncology, Hematology, BMT with Section Pneumology, Hubertus-Wald-Tumorzentrum/University Cancer Center Hamburg (UCCH) University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Guido Sauter,

Affiliation Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Hartwig Huland,

Affiliation Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Thorsten Schlomm,

Affiliation Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯
Sarah Minner

Affiliation Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⨯

Loss of Somatostatin Receptor Subtype 2 in Prostate Cancer Is Linked to an Aggressive Cancer Phenotype, High Tumor Cell Proliferation and Predicts Early Metastatic and Biochemical Relapse

Jan K. Hennigs,
Julia Müller,
Matti Adam,
Joshua M. Spin,
Emilia Riedel,
Markus Graefen,
Carsten Bokemeyer,
Guido Sauter,
Hartwig Huland,
Thorsten Schlomm

Published: July 10, 2014
https://doi.org/10.1371/journal.pone.0100469

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Breast cancer
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Immunohistochemistry techniques
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Gene expression
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