Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway

Yohko Yoshida; Yuka Hayashi; Masayoshi Suda; Kaoru Tateno; Sho Okada; Junji Moriya; Masataka Yokoyama; Aika Nojima; Masakatsu Yamashita; Yoshio Kobayashi; Ippei Shimizu; Tohru Minamino

doi:10.1371/journal.pone.0100359

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Open Access

Peer-reviewed

Research Article

Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway

Yohko Yoshida ,

Contributed equally to this work with: Yohko Yoshida, Yuka Hayashi

Affiliation Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Yuka Hayashi ,

Contributed equally to this work with: Yohko Yoshida, Yuka Hayashi

Affiliation Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Masayoshi Suda,

Affiliation Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Kaoru Tateno,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Sho Okada,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Junji Moriya,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Masataka Yokoyama,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Aika Nojima,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Masakatsu Yamashita,

Affiliation Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
⨯
Yoshio Kobayashi,

Affiliation Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Ippei Shimizu,

Affiliation Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Tohru Minamino

* E-mail: t_minamino@yahoo.co.jp

Affiliations Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
⨯

Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway

Yohko Yoshida,
Yuka Hayashi,
Masayoshi Suda,
Kaoru Tateno,
Sho Okada,
Junji Moriya,
Masataka Yokoyama,
Aika Nojima,
Masakatsu Yamashita,
Yoshio Kobayashi

Published: June 20, 2014
https://doi.org/10.1371/journal.pone.0100359

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