Batch Effect Confounding Leads to Strong Bias in Performance Estimates Obtained by Cross-Validation

• Charlotte Soneson ,

  Contributed equally to this work with: Charlotte Soneson, Sarah Gerster

  * E-mail: charlotte.soneson@isb-sib.ch

  Affiliation SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland

  ⨯
• Sarah Gerster ,

  Contributed equally to this work with: Charlotte Soneson, Sarah Gerster

  Affiliation SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland

  ⨯
• Mauro Delorenzi

  Affiliations SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland, Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland, Oncology Department, University of Lausanne, Lausanne, Switzerland

  ⨯