High-Throughput Sequencing Analysis of Post-Liver Transplantation HCV E2 Glycoprotein Evolution in the Presence and Absence of Neutralizing Monoclonal Antibody

Gregory J. Babcock; Sowmya Iyer; Heidi L. Smith; Yang Wang; Kirk Rowley; Donna M. Ambrosino; Phillip D. Zamore; Brian G. Pierce; Deborah C. Molrine; Zhiping Weng

doi:10.1371/journal.pone.0100325

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Peer-reviewed

Research Article

High-Throughput Sequencing Analysis of Post-Liver Transplantation HCV E2 Glycoprotein Evolution in the Presence and Absence of Neutralizing Monoclonal Antibody

Gregory J. Babcock ,

Contributed equally to this work with: Gregory J. Babcock, Sowmya Iyer, Heidi L. Smith

Affiliation MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
⨯
Sowmya Iyer ,

Contributed equally to this work with: Gregory J. Babcock, Sowmya Iyer, Heidi L. Smith

Affiliations Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America
⨯
Heidi L. Smith ,

Contributed equally to this work with: Gregory J. Babcock, Sowmya Iyer, Heidi L. Smith

Affiliation MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
⨯
Yang Wang,

Affiliation MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
⨯
Kirk Rowley,

Affiliation MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
⨯
Donna M. Ambrosino,

Affiliation MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
⨯
Phillip D. Zamore,

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Brian G. Pierce,

Affiliation Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Deborah C. Molrine,

Affiliation MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
⨯
Zhiping Weng

* E-mail: zhiping.weng@umassmed.edu

Affiliation Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

High-Throughput Sequencing Analysis of Post-Liver Transplantation HCV E2 Glycoprotein Evolution in the Presence and Absence of Neutralizing Monoclonal Antibody

Gregory J. Babcock,
Sowmya Iyer,
Heidi L. Smith,
Yang Wang,
Kirk Rowley,
Donna M. Ambrosino,
Phillip D. Zamore,
Brian G. Pierce,
Deborah C. Molrine,
Zhiping Weng

Published: June 23, 2014
https://doi.org/10.1371/journal.pone.0100325

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Hepatitis C virus
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Liver transplantation
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RNA sequencing
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Viral evolution
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