Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates

• Vibha Singhal ,

  ¶These authors are joint first authors on this work.

  Affiliations Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, United States of America

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• Elizabeth A. Lawson ,

  ¶These authors are joint first authors on this work.

  Affiliation Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Kathryn E. Ackerman,

  Affiliations Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Sports Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Pouneh K. Fazeli,

  Affiliation Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Hannah Clarke,

  Affiliation Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Hang Lee,

  Affiliation Department of Biostatistics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Kamryn Eddy,

  Affiliations Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Harris Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Dean A. Marengi,

  Affiliation Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Nicholas P. Derrico,

  Affiliation Endocrine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Mary L. Bouxsein,

  Affiliations Endocrine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

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• Madhusmita Misra

  * E-mail: mmisra@partners.org (MM)

  Affiliations Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts, United States of America

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