From Pan-Reactive K_V7 Channel Opener to Subtype Selective Opener/Inhibitor by Addition of a Methyl Group

• Sigrid Marie Blom,

  Current address: Nansen Neuroscience Network, Oslo, Norway

  Affiliations Division of Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark, Department of Biomedical Sciences and Danish National Research Foundation Centre for Cardiac Arrhythmia, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Mario Rottländer,

  Current address: Department of Medicinal Chemistry, Zealand Pharma A/S, Glostrup, Denmark

  Affiliation Division of Discovery Chemistry and DMPK, H. Lundbeck A/S, Copenhagen, Denmark

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• Jan Kehler,

  Affiliation Division of Discovery Chemistry and DMPK, H. Lundbeck A/S, Copenhagen, Denmark

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• Christoffer Bundgaard,

  Affiliation Division of Discovery Chemistry and DMPK, H. Lundbeck A/S, Copenhagen, Denmark

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• Nicole Schmitt,

  Affiliation Department of Biomedical Sciences and Danish National Research Foundation Centre for Cardiac Arrhythmia, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Henrik Sindal Jensen

  * E-mail: HSIN@Lundbeck.com

  Affiliation Division of Neuroscience Drug Discovery, H. Lundbeck A/S, Copenhagen, Denmark

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