HIV Treatments Reduce Malaria Liver Stage Burden in a Non-Human Primate Model of Malaria Infection at Clinically Relevant Concentrations In Vivo

Charlotte V. Hobbs; Jillian Neal; Solomon Conteh; Liam Donnelly; Jingyang Chen; Kennan Marsh; Lynn Lambert; Sachy Orr-Gonzalez; Jessica Hinderer; Sara Healy; William Borkowsky; Scott R. Penzak; Sumana Chakravarty; Stephen L. Hoffman; Patrick E. Duffy

doi:10.1371/journal.pone.0100138

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Open Access

Peer-reviewed

Research Article

HIV Treatments Reduce Malaria Liver Stage Burden in a Non-Human Primate Model of Malaria Infection at Clinically Relevant Concentrations In Vivo

Charlotte V. Hobbs ,

* E-mail: charlotte.hobbs@nih.gov

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Jillian Neal,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
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Solomon Conteh,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Liam Donnelly,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Jingyang Chen,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Kennan Marsh,

Affiliation AbbVie Inc., North Chicago, Illinois, United States of America
⨯
Lynn Lambert,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Sachy Orr-Gonzalez,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Jessica Hinderer,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯
Sara Healy,

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
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William Borkowsky,

Affiliation Division of Infectious Disease and Immunology, Department of Pediatrics, New York University School of Medicine, New York, New York, United States of America
⨯
Scott R. Penzak,

Current address: University of North Texas System College of Pharmacy, Forth Worth, Texas, United States of America

Affiliation Clinical Center Pharmacy Department, Clinical Pharmacokinetics Research Laboratory, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
⨯
Sumana Chakravarty,

Affiliation Sanaria, Inc. Rockville, Maryland, United States of America
⨯
Stephen L. Hoffman,

Affiliation Sanaria, Inc. Rockville, Maryland, United States of America
⨯
Patrick E. Duffy

Affiliation Laboratory of Malaria Immunology and Vaccinology, National Institutes of Health/National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
⨯

HIV Treatments Reduce Malaria Liver Stage Burden in a Non-Human Primate Model of Malaria Infection at Clinically Relevant Concentrations In Vivo

Charlotte V. Hobbs,
Jillian Neal,
Solomon Conteh,
Liam Donnelly,
Jingyang Chen,
Kennan Marsh,
Lynn Lambert,
Sachy Orr-Gonzalez,
Jessica Hinderer,
Sara Healy

Published: July 2, 2014
https://doi.org/10.1371/journal.pone.0100138

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