High-Resolution Quantification of Hepatitis C Virus Genome-Wide Mutation Load and Its Correlation with the Outcome of Peginterferon-Alpha2a and Ribavirin Combination Therapy

Weihua Wang; Xiaoan Zhang; Yanjuan Xu; George M. Weinstock; Adrian M. Di Bisceglie; Xiaofeng Fan

doi:10.1371/journal.pone.0100131

Loading metrics

Open Access

Peer-reviewed

Research Article

High-Resolution Quantification of Hepatitis C Virus Genome-Wide Mutation Load and Its Correlation with the Outcome of Peginterferon-Alpha2a and Ribavirin Combination Therapy

Weihua Wang,

Affiliations Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Wuhan Center for Tuberculosis Control, Wuhan, Hubei, China
⨯
Xiaoan Zhang,

Affiliation Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yanjuan Xu,

Affiliation Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
George M. Weinstock,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Adrian M. Di Bisceglie ,

* E-mail: dibiscam@slu.edu (AMD); fanx@slu.edu (XF)

Affiliations Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
Xiaofeng Fan

* E-mail: dibiscam@slu.edu (AMD); fanx@slu.edu (XF)

Affiliations Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯

High-Resolution Quantification of Hepatitis C Virus Genome-Wide Mutation Load and Its Correlation with the Outcome of Peginterferon-Alpha2a and Ribavirin Combination Therapy

Weihua Wang,
Xiaoan Zhang,
Yanjuan Xu,
George M. Weinstock,
Adrian M. Di Bisceglie,
Xiaofeng Fan

Published: June 20, 2014
https://doi.org/10.1371/journal.pone.0100131

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Microbial mutation
Is the Subject Area "Microbial mutation" applicable to this article?

Thanks for your feedback.
Antiviral therapy
Is the Subject Area "Antiviral therapy" applicable to this article?

Thanks for your feedback.
Hepatitis C virus
Is the Subject Area "Hepatitis C virus" applicable to this article?

Thanks for your feedback.
Mutation detection
Is the Subject Area "Mutation detection" applicable to this article?

Thanks for your feedback.
Phylogenetic analysis
Is the Subject Area "Phylogenetic analysis" applicable to this article?

Thanks for your feedback.
Reverse transcriptase-polymerase chain reaction
Is the Subject Area "Reverse transcriptase-polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Viral structure
Is the Subject Area "Viral structure" applicable to this article?

Thanks for your feedback.
RNA structure
Is the Subject Area "RNA structure" applicable to this article?

Thanks for your feedback.