Dengue Type Four Viruses with E-Glu₃₄₅Lys Adaptive Mutation from MRC-5 Cells Induce Low Viremia but Elicit Potent Neutralizing Antibodies in Rhesus Monkeys

• Hsiao-Han Lin ,

  Contributed equally to this work with: Hsiao-Han Lin, Hsiang-Chi Lee

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Hsiang-Chi Lee ,

  Contributed equally to this work with: Hsiao-Han Lin, Hsiang-Chi Lee

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Xiao-Feng Li,

  Affiliation Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Meng-Ju Tsai,

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Hung-Ju Hsiao,

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Jia-Guan Peng,

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Shih-Che Sue,

  Affiliation Institute of Bioinformatics and Structural Biology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Cheng-Feng Qin ,

  * E-mail: scwu@mx.nthu.edu.tw (SCW); qincf@bmi.ac.cn (CFQ)

  Affiliation Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Suh-Chin Wu

  * E-mail: scwu@mx.nthu.edu.tw (SCW); qincf@bmi.ac.cn (CFQ)

  Affiliations Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan

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