Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

Romana Koppensteiner; Eleftherios P. Samartzis; Aurelia Noske; Adriana von Teichman; Ioannis Dedes; Myriam Gwerder; Patrick Imesch; Kristian Ikenberg; Holger Moch; Daniel Fink; Manuel Stucki; Konstantin J. Dedes

doi:10.1371/journal.pone.0100041

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Open Access

Peer-reviewed

Research Article

Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

Romana Koppensteiner ,

Contributed equally to this work with: Romana Koppensteiner, Eleftherios P. Samartzis

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Eleftherios P. Samartzis ,

Contributed equally to this work with: Romana Koppensteiner, Eleftherios P. Samartzis

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Aurelia Noske,

Affiliation Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
⨯
Adriana von Teichman,

Affiliation Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
⨯
Ioannis Dedes,

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Myriam Gwerder,

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Patrick Imesch,

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Kristian Ikenberg,

Affiliation Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
⨯
Holger Moch,

Affiliation Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
⨯
Daniel Fink,

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Manuel Stucki,

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯
Konstantin J. Dedes

* E-mail: Konstantin.Dedes@usz.ch

Affiliation Division of Gynaecology, University Hospital of Zurich, Zurich, Switzerland
⨯

Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

Romana Koppensteiner,
Eleftherios P. Samartzis,
Aurelia Noske,
Adriana von Teichman,
Ioannis Dedes,
Myriam Gwerder,
Patrick Imesch,
Kristian Ikenberg,
Holger Moch,
Daniel Fink

Published: June 13, 2014
https://doi.org/10.1371/journal.pone.0100041

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Cancer treatment
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Uterine cancer
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Mutation
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Protein expression
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DNA repair
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Small interfering RNA
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