Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

Canhui Yi; Yong Zhang; Zhenlong Yu; Yao Xiao; Jingshu Wang; Huijuan Qiu; Wendan Yu; Ranran Tang; Yuhui Yuan; Wei Guo; Wuguo Deng

doi:10.1371/journal.pone.0099943

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Open Access

Peer-reviewed

Research Article

Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

Canhui Yi ,

Contributed equally to this work with: Canhui Yi, Yong Zhang

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, The First Affiliated Hospital, Dalian Medical University Cancer Center, Dalian, China
⨯
Yong Zhang ,

Contributed equally to this work with: Canhui Yi, Yong Zhang

Affiliation Department of Neurosurgery, Guangdong No. 2 Provincial People's Hospital, Guangzhou, China
⨯
Zhenlong Yu,

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, The First Affiliated Hospital, Dalian Medical University Cancer Center, Dalian, China
⨯
Yao Xiao,

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China
⨯
Jingshu Wang,

Affiliation Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China
⨯
Huijuan Qiu,

Affiliation Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China
⨯
Wendan Yu,

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China
⨯
Ranran Tang,

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, The First Affiliated Hospital, Dalian Medical University Cancer Center, Dalian, China
⨯
Yuhui Yuan,

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, The First Affiliated Hospital, Dalian Medical University Cancer Center, Dalian, China
⨯
Wei Guo ,

* E-mail: wei1015@msn.com (WG); dengwg@sysucc.org.cn (WD)

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, The First Affiliated Hospital, Dalian Medical University Cancer Center, Dalian, China
⨯
Wuguo Deng

* E-mail: wei1015@msn.com (WG); dengwg@sysucc.org.cn (WD)

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China, The First Affiliated Hospital, Dalian Medical University Cancer Center, Dalian, China
⨯

Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

Canhui Yi,
Yong Zhang,
Zhenlong Yu,
Yao Xiao,
Jingshu Wang,
Huijuan Qiu,
Wendan Yu,
Ranran Tang,
Yuhui Yuan,
Wei Guo

Published: July 7, 2014
https://doi.org/10.1371/journal.pone.0099943

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Melatonin
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Cancer treatment
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Melanoma cells
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