Individual with Subclinical Atherosclerosis Have Impaired Proliferation of Blood Outgrowth Endothelial Cells, Which Can Be Restored by Statin Therapy

Javier Martin-Ramirez; Maayke G. M. Kok; Menno Hofman; Ruben Bierings; Esther E. Creemers; Joost C. M. Meijers; Jan Voorberg; Sara-Joan Pinto-Sietsma

doi:10.1371/journal.pone.0099890

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Open Access

Peer-reviewed

Research Article

Individual with Subclinical Atherosclerosis Have Impaired Proliferation of Blood Outgrowth Endothelial Cells, Which Can Be Restored by Statin Therapy

Javier Martin-Ramirez ,

Contributed equally to this work with: Javier Martin-Ramirez, Maayke G. M. Kok

Affiliation Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands
⨯
Maayke G. M. Kok ,

Contributed equally to this work with: Javier Martin-Ramirez, Maayke G. M. Kok

Affiliations Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands, Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
⨯
Menno Hofman,

Affiliation Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands
⨯
Ruben Bierings,

Affiliation Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands
⨯
Esther E. Creemers,

Affiliation The Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
⨯
Joost C. M. Meijers,

Affiliations Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands, Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
⨯
Jan Voorberg,

Affiliation Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands
⨯
Sara-Joan Pinto-Sietsma

* E-mail: S.J.Pinto@amc.uva.nl

Affiliations Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
⨯

Individual with Subclinical Atherosclerosis Have Impaired Proliferation of Blood Outgrowth Endothelial Cells, Which Can Be Restored by Statin Therapy

Javier Martin-Ramirez,
Maayke G. M. Kok,
Menno Hofman,
Ruben Bierings,
Esther E. Creemers,
Joost C. M. Meijers,
Jan Voorberg,
Sara-Joan Pinto-Sietsma

Published: June 23, 2014
https://doi.org/10.1371/journal.pone.0099890

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Atherosclerosis
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Statins
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Coronary heart disease
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Cardiovascular diseases
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Computed axial tomography
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Endothelial cells
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Cardiovascular disease risk
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Cholesterol
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