Pleiotropic Effect of AccD5 and AccE5 Depletion in Acyl-Coenzyme A Carboxylase Activity and in Lipid Biosynthesis in Mycobacteria

Bernardo Bazet Lyonnet; Lautaro Diacovich; Matías Cabruja; Fabienne Bardou; Annaïk Quémard; Gabriela Gago; Hugo Gramajo

doi:10.1371/journal.pone.0099853

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Research Article

Pleiotropic Effect of AccD5 and AccE5 Depletion in Acyl-Coenzyme A Carboxylase Activity and in Lipid Biosynthesis in Mycobacteria

Bernardo Bazet Lyonnet,

Affiliation Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
⨯
Lautaro Diacovich,

Affiliation Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
⨯
Matías Cabruja,

Affiliation Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
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Fabienne Bardou,

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Département Tuberculose et Biologie des Infections, Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
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Annaïk Quémard,

Affiliations CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Département Tuberculose et Biologie des Infections, Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France
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Gabriela Gago ,

* E-mail: gago@ibr-conicet.gov.ar (GG); gramajo@ibr-conicet.gov.ar (HG)

Affiliation Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
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Hugo Gramajo

* E-mail: gago@ibr-conicet.gov.ar (GG); gramajo@ibr-conicet.gov.ar (HG)

Affiliation Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
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Pleiotropic Effect of AccD5 and AccE5 Depletion in Acyl-Coenzyme A Carboxylase Activity and in Lipid Biosynthesis in Mycobacteria

Bernardo Bazet Lyonnet,
Lautaro Diacovich,
Matías Cabruja,
Fabienne Bardou,
Annaïk Quémard,
Gabriela Gago,
Hugo Gramajo

Published: June 20, 2014
https://doi.org/10.1371/journal.pone.0099853

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30 Jul 2014
08:53 GMT
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A Letter to the Editor: Function of Mycobacterial ACCases – conclusions and speculations Posted by jdziadek on 30 Jul 2014 at 08:53 GMT

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