A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

Romeo Cecchelli; Sezin Aday; Emmanuel Sevin; Catarina Almeida; Maxime Culot; Lucie Dehouck; Caroline Coisne; Britta Engelhardt; Marie-Pierre Dehouck; Lino Ferreira

doi:10.1371/journal.pone.0099733

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Peer-reviewed

Research Article

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

Romeo Cecchelli ,

Contributed equally to this work with: Romeo Cecchelli, Sezin Aday

Affiliation Blood Brain Barrier Laboratory, University of Artois, Lens, France
⨯
Sezin Aday ,

Contributed equally to this work with: Romeo Cecchelli, Sezin Aday

Affiliations CNC - Center of Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Biomaterials and Stem Cell-based Therapeutics Laboratory, Biocant - Center of Innovation in Biotechnology, Cantanhede, Portugal
⨯
Emmanuel Sevin,

Affiliation Blood Brain Barrier Laboratory, University of Artois, Lens, France
⨯
Catarina Almeida,

Affiliations CNC - Center of Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Biomaterials and Stem Cell-based Therapeutics Laboratory, Biocant - Center of Innovation in Biotechnology, Cantanhede, Portugal, Institute for Interdisciplinary Research, University of Coimbra (IIIUC), Coimbra, Portugal
⨯
Maxime Culot,

Affiliation Blood Brain Barrier Laboratory, University of Artois, Lens, France
⨯
Lucie Dehouck,

Affiliation Blood Brain Barrier Laboratory, University of Artois, Lens, France
⨯
Caroline Coisne,

Affiliation Theodor Kocher Institute, University of Bern, Bern, Switzerland
⨯
Britta Engelhardt,

Affiliation Theodor Kocher Institute, University of Bern, Bern, Switzerland
⨯
Marie-Pierre Dehouck,

Affiliation Blood Brain Barrier Laboratory, University of Artois, Lens, France
⨯
Lino Ferreira

* E-mail: lino@biocant.pt

Affiliations CNC - Center of Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal, Biomaterials and Stem Cell-based Therapeutics Laboratory, Biocant - Center of Innovation in Biotechnology, Cantanhede, Portugal
⨯

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

Romeo Cecchelli,
Sezin Aday,
Emmanuel Sevin,
Catarina Almeida,
Maxime Culot,
Lucie Dehouck,
Caroline Coisne,
Britta Engelhardt,
Marie-Pierre Dehouck,
Lino Ferreira

Published: June 17, 2014
https://doi.org/10.1371/journal.pone.0099733

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Blood-brain barrier
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