Activation of JNK Contributes to Evodiamine-Induced Apoptosis and G₂/M Arrest in Human Colorectal Carcinoma Cells: A Structure-Activity Study of Evodiamine

• Chih-Chiang Chien ,

  Contributed equally to this work with: Chih-Chiang Chien, Ming-Shun Wu, Shing-Chuan Shen

  Affiliations Department of Nephrology, Chi-Mei Medical Center, Tainan, Taiwan, Department of Food Nutrition, Chung Hwa University of Medical Technology, Tainan, Taiwan

  ⨯
• Ming-Shun Wu ,

  Contributed equally to this work with: Chih-Chiang Chien, Ming-Shun Wu, Shing-Chuan Shen

  Affiliation Division of Gastroenterology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

  ⨯
• Shing-Chuan Shen ,

  Contributed equally to this work with: Chih-Chiang Chien, Ming-Shun Wu, Shing-Chuan Shen

  Affiliation Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan

  ⨯
• Ching-Huai Ko,

  Affiliation Strategic Business and Innovation Technology Development Division, and Biomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu, Taiwan

  ⨯
• Chih-Hung Chen,

  Affiliation Strategic Business and Innovation Technology Development Division, and Biomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu, Taiwan

  ⨯
• Ling-Ling Yang,

  Affiliation College of LOHAS, Fo Guang University, Yilan, Taiwan

  ⨯
• Yen-Chou Chen

  * E-mail: yc3270@tmu.edu.tw

  Affiliations Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, Cancer Research Center and Orthopedics Research Center, Taipei Medical University Hospital, Taipei, Taiwan

  ⨯