The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats

Yi Zhao; Cheng Zhou; Jin Liu; Peng Liang; Daqing Liao; Yanfang Chen; Xiangdong Chen

doi:10.1371/journal.pone.0099704

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Peer-reviewed

Research Article

The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats

Yi Zhao ,

Contributed equally to this work with: Yi Zhao, Cheng Zhou

Affiliation Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
⨯
Cheng Zhou ,

Contributed equally to this work with: Yi Zhao, Cheng Zhou

Affiliation Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
⨯
Jin Liu ,

* E-mail: scujinliu@gmail.com (JL) (JL); xiangdongchen2013@163.com (XC) (XC)

Affiliation Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
⨯
Peng Liang,

Affiliation Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
⨯
Daqing Liao,

Affiliation Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
⨯
Yanfang Chen,

Affiliation Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China
⨯
Xiangdong Chen

* E-mail: scujinliu@gmail.com (JL) (JL); xiangdongchen2013@163.com (XC) (XC)

Affiliations Department of Anesthesiology and Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China, Department of Anesthesiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China
⨯

The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats

Yi Zhao,
Cheng Zhou,
Jin Liu,
Peng Liang,
Daqing Liao,
Yanfang Chen,
Xiangdong Chen

Published: June 16, 2014
https://doi.org/10.1371/journal.pone.0099704

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