Hybrid Lentivirus-phiC31-int-NLS Vector Allows Site-Specific Recombination in Murine and Human Cells but Induces DNA Damage

Nicolas Grandchamp; Dorothée Altémir; Stéphanie Philippe; Suzanna Ursulet; Héloïse Pilet; Marie-Claude Serre; Aude Lenain; Che Serguera; Jacques Mallet; Chamsy Sarkis

doi:10.1371/journal.pone.0099649

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Peer-reviewed

Research Article

Hybrid Lentivirus-phiC31-int-NLS Vector Allows Site-Specific Recombination in Murine and Human Cells but Induces DNA Damage

Nicolas Grandchamp,

Affiliations Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France, NewVectys, Villebon-sur-Yvette, France, Biosource, Paris, France
⨯
Dorothée Altémir,

Affiliations Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France, NewVectys, Villebon-sur-Yvette, France
⨯
Stéphanie Philippe,

Affiliations Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France, NewVectys, Villebon-sur-Yvette, France, Biosource, Paris, France
⨯
Suzanna Ursulet,

Affiliations Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France, NewVectys, Villebon-sur-Yvette, France, Biosource, Paris, France
⨯
Héloïse Pilet,

Affiliations Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France, NewVectys, Villebon-sur-Yvette, France, Biosource, Paris, France
⨯
Marie-Claude Serre,

Affiliation Laboratoire de Virologie Moléculaire et Structurale, Gif-sur-Yvette, France
⨯
Aude Lenain,

Affiliation Commissariat à l'Energie Atomique, Laboratoire de Radiobiologie et Oncologie, Fontenay-aux-Roses, France
⨯
Che Serguera,

Affiliation Molecular Imaging Research Center - Modélisation des biothérapies, Fontenay-aux-Roses, France
⨯
Jacques Mallet,

Affiliation Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France
⨯
Chamsy Sarkis

* E-mail: chamsy.sarkis@newvectys.com

Affiliations Unit of Biotechnology and Biotherapy, Centre de recherche de l'Institut du Cerveau et de la Moelle Epinière, Pierre-and-Marie-Curie University/Institut National de la Santé et de la Recherche Médicale, Paris, France, NewVectys, Villebon-sur-Yvette, France
⨯

Hybrid Lentivirus-phiC31-int-NLS Vector Allows Site-Specific Recombination in Murine and Human Cells but Induces DNA Damage

Nicolas Grandchamp,
Dorothée Altémir,
Stéphanie Philippe,
Suzanna Ursulet,
Héloïse Pilet,
Marie-Claude Serre,
Aude Lenain,
Che Serguera,
Jacques Mallet,
Chamsy Sarkis

Published: June 23, 2014
https://doi.org/10.1371/journal.pone.0099649

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