Heterogeneous EGFR Gene Copy Number Increase Is Common in Colorectal Cancer and Defines Response to Anti-EGFR Therapy

• Annika Ålgars,

  Affiliation Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland

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• Tuulia Avoranta ,

  Contributed equally to this work with: Tuulia Avoranta, Pia Österlund

  Affiliation Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland

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• Pia Österlund ,

  Contributed equally to this work with: Tuulia Avoranta, Pia Österlund

  Affiliations Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland, Department of Oncology, University of Helsinki, Helsinki, Finland

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• Minnamaija Lintunen,

  Affiliations Department of Pathology, University of Turku, Turku, Finland, Department of Pathology, Turku University Hospital –Tyks-Sapa, Turku, Finland

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• Jari Sundström,

  Affiliations Department of Pathology, University of Turku, Turku, Finland, Department of Pathology, Turku University Hospital –Tyks-Sapa, Turku, Finland

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• Terhi Jokilehto,

  Affiliations Department of Pathology, University of Turku, Turku, Finland, Department of Pathology, Turku University Hospital –Tyks-Sapa, Turku, Finland

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• Ari Ristimäki,

  Affiliations Division of Pathology and Genetics, Helsinki University Central Hospital - HUSLAB, Helsinki, Finland, Department of Pathology, Haartman Institute and Genome-Scale Biology, Research Programs Unit, University of Helsinki, Helsinki, Finland

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• Raija Ristamäki,

  Affiliation Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland

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• Olli Carpén

  * E-mail: ocarpen@utu.fi

  Affiliations Department of Pathology, University of Turku, Turku, Finland, Department of Pathology, Turku University Hospital –Tyks-Sapa, Turku, Finland

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