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Open Access

Peer-reviewed

Research Article

A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth

Liwei Lang ,

Contributed equally to this work with: Liwei Lang, Xiaoyu Liu

Affiliations Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China, GRU Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Xiaoyu Liu ,

Contributed equally to this work with: Liwei Lang, Xiaoyu Liu

Affiliation Department of Synthetic Medicinal Chemistry, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China
⨯
Yan Li,

Affiliation Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China
⨯
Qing Zhou,

Affiliation Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China
⨯
Ping Xie,

Affiliation Department of Synthetic Medicinal Chemistry, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China
⨯
Chunhong Yan ,

* E-mail: chxg@imm.ac.cn (XC); cyan@gru.edu (CY)

Affiliation GRU Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Xiaoguang Chen

* E-mail: chxg@imm.ac.cn (XC); cyan@gru.edu (CY)

Affiliation Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China
⨯

A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth

Liwei Lang,
Xiaoyu Liu,
Yan Li,
Qing Zhou,
Ping Xie,
Chunhong Yan,
Xiaoguang Chen

x

Published: June 12, 2014
https://doi.org/10.1371/journal.pone.0099584

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Lung and intrathoracic tumors
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Hypoxia
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Chemical synthesis
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