ZO-1 and ZO-2 Are Required for Extra-Embryonic Endoderm Integrity, Primitive Ectoderm Survival and Normal Cavitation in Embryoid Bodies Derived from Mouse Embryonic Stem Cells

Dominic C. Y. Phua; Jianliang Xu; Safiah Mohamed Ali; Adrian Boey; Natalia V. Gounko; Walter Hunziker

doi:10.1371/journal.pone.0099532

Loading metrics

Open Access

Peer-reviewed

Research Article

ZO-1 and ZO-2 Are Required for Extra-Embryonic Endoderm Integrity, Primitive Ectoderm Survival and Normal Cavitation in Embryoid Bodies Derived from Mouse Embryonic Stem Cells

Dominic C. Y. Phua ,

Contributed equally to this work with: Dominic C. Y. Phua, Jianliang Xu

Affiliation Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
⨯
Jianliang Xu ,

Contributed equally to this work with: Dominic C. Y. Phua, Jianliang Xu

Affiliation Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
⨯
Safiah Mohamed Ali,

Affiliation Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
⨯
Adrian Boey,

Affiliations Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore, IMB-IMCB Joint Electron Microscopy Suite, Agency for Science Technology and Research (A*STAR), Singapore, Singapore
⨯
Natalia V. Gounko,

Affiliations Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore, IMB-IMCB Joint Electron Microscopy Suite, Agency for Science Technology and Research (A*STAR), Singapore, Singapore
⨯
Walter Hunziker

* E-mail: hunziker@imcb.a-star.edu.sg

Affiliations Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Singapore, Department of Physiology, National University of Singapore and Singapore Eye Research Institute (SERI), Singapore, Singapore
⨯

ZO-1 and ZO-2 Are Required for Extra-Embryonic Endoderm Integrity, Primitive Ectoderm Survival and Normal Cavitation in Embryoid Bodies Derived from Mouse Embryonic Stem Cells

Dominic C. Y. Phua,
Jianliang Xu,
Safiah Mohamed Ali,
Adrian Boey,
Natalia V. Gounko,
Walter Hunziker

Published: June 6, 2014
https://doi.org/10.1371/journal.pone.0099532

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Permeability
Is the Subject Area "Permeability" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Epithelium
Is the Subject Area "Epithelium" applicable to this article?

Thanks for your feedback.
Endoderm
Is the Subject Area "Endoderm" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Membrane staining
Is the Subject Area "Membrane staining" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.