Quantification of Functionalised Gold Nanoparticle-Targeted Knockdown of Gene Expression in HeLa Cells

Meesbah Jiwaji; Mairi E. Sandison; Julien Reboud; Ross Stevenson; Rónán Daly; Gráinne Barkess; Karen Faulds; Walter Kolch; Duncan Graham; Mark A. Girolami; Jonathan M. Cooper; Andrew R. Pitt

doi:10.1371/journal.pone.0099458

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Open Access

Peer-reviewed

Research Article

Quantification of Functionalised Gold Nanoparticle-Targeted Knockdown of Gene Expression in HeLa Cells

Meesbah Jiwaji,

Affiliations Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, School of Life and Health Science, Aston University, Birmingham, United Kingdom
⨯
Mairi E. Sandison,

Affiliations Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom
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Julien Reboud,

Affiliation Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom
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Ross Stevenson,

Affiliation Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
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Rónán Daly,

Affiliation School of Computing Science, University of Glasgow, Glasgow, United Kingdom
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Gráinne Barkess,

Affiliation Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Karen Faulds,

Affiliation Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
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Walter Kolch,

Affiliations Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Systems Biology Ireland and the Conway Institute, University College Dublin, Belfield, Dublin, Ireland
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Duncan Graham,

Affiliation Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
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Mark A. Girolami,

Affiliations School of Computing Science, University of Glasgow, Glasgow, United Kingdom, Department of Statistical Science, University College London, London, United Kingdom
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Jonathan M. Cooper,

Affiliation Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom
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Andrew R. Pitt

* E-mail: a.r.pitt@aston.ac.uk

Affiliations Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, School of Life and Health Science, Aston University, Birmingham, United Kingdom
⨯

Quantification of Functionalised Gold Nanoparticle-Targeted Knockdown of Gene Expression in HeLa Cells

Meesbah Jiwaji,
Mairi E. Sandison,
Julien Reboud,
Ross Stevenson,
Rónán Daly,
Gráinne Barkess,
Karen Faulds,
Walter Kolch,
Duncan Graham,
Mark A. Girolami

Published: June 13, 2014
https://doi.org/10.1371/journal.pone.0099458

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Nanoparticles
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Transfection
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HeLa cells
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Gene expression
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Small interfering RNA
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Messenger RNA
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Fluorescence imaging
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Oligonucleotides
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