BRCA1 Silencing Is Associated with Failure of DNA Repairing in Retinal Neurocytes

Pei Chen; Huan Hu; Zhao Chen; Xiaoxiao Cai; Zhang Zhang; Ying Yang; Na Yu; Jing Zhang; Lei Xia; Jian Ge; Keming Yu; Jing Zhuang

doi:10.1371/journal.pone.0099371

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Open Access

Peer-reviewed

Research Article

BRCA1 Silencing Is Associated with Failure of DNA Repairing in Retinal Neurocytes

Pei Chen ,

Contributed equally to this work with: Pei Chen, Huan Hu

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Huan Hu ,

Contributed equally to this work with: Pei Chen, Huan Hu

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Zhao Chen,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Xiaoxiao Cai,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Zhang Zhang,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Ying Yang,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Na Yu,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Jing Zhang,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Lei Xia,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Jian Ge,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Keming Yu,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯
Jing Zhuang

* E-mail: zhuangj@mail.sysu.edu.cn

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdon, P. R. China
⨯

BRCA1 Silencing Is Associated with Failure of DNA Repairing in Retinal Neurocytes

Pei Chen,
Huan Hu,
Zhao Chen,
Xiaoxiao Cai,
Zhang Zhang,
Ying Yang,
Na Yu,
Jing Zhang,
Lei Xia,
Jian Ge

Published: June 11, 2014
https://doi.org/10.1371/journal.pone.0099371

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Non-homologous end joining
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DNA repair
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Small interfering RNA
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Neurons
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DNA damage
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Retina
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Precursor cells
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Neuronal differentiation
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