Anti-Hypotensive Treatment and Endothelin Blockade Synergistically Antagonize Exercise Fatigue in Rats under Simulated High Altitude

Daniel Radiloff; Yulin Zhao; Alina Boico; Gert Blueschke; Gregory Palmer; Andrew Fontanella; Mark Dewhirst; Claude A. Piantadosi; Robert Noveck; David Irwin; Karyn Hamilton; Bruce Klitzman; Thies Schroeder

doi:10.1371/journal.pone.0099309

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Open Access

Peer-reviewed

Research Article

Anti-Hypotensive Treatment and Endothelin Blockade Synergistically Antagonize Exercise Fatigue in Rats under Simulated High Altitude

Daniel Radiloff,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Yulin Zhao,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Alina Boico,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Gert Blueschke,

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Gregory Palmer,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Andrew Fontanella,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Mark Dewhirst,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Claude A. Piantadosi,

Affiliation Department of Medicine-Pulmonary, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Robert Noveck,

Affiliation Department of Medicine-Clinical Pharmacology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
David Irwin,

Affiliation Department of Cardiology, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Karyn Hamilton,

Affiliation Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Bruce Klitzman,

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Thies Schroeder

* E-mail: tschroeder28@gmail.com

Affiliation Department of Physical Chemistry, University of Mainz, Mainz, Germany
⨯

Anti-Hypotensive Treatment and Endothelin Blockade Synergistically Antagonize Exercise Fatigue in Rats under Simulated High Altitude

Daniel Radiloff,
Yulin Zhao,
Alina Boico,
Gert Blueschke,
Gregory Palmer,
Andrew Fontanella,
Mark Dewhirst,
Claude A. Piantadosi,
Robert Noveck,
David Irwin

Published: June 24, 2014
https://doi.org/10.1371/journal.pone.0099309

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