Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

Laïla-Aïcha Hanafi; Dominique Gauchat; Jessica Godin-Ethier; David Possamaï; Jean-Baptiste Duvignaud; Denis Leclerc; Nathalie Grandvaux; Réjean Lapointe

doi:10.1371/journal.pone.0099211

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Open Access

Peer-reviewed

Research Article

Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

Laïla-Aïcha Hanafi,

Affiliation Research Centre, Centre hospitalier de l′Université de Montréal (CRCHUM), Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada
⨯
Dominique Gauchat,

Affiliation Research Centre, Centre hospitalier de l′Université de Montréal (CRCHUM), Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada
⨯
Jessica Godin-Ethier,

Affiliation Research Centre, Centre hospitalier de l′Université de Montréal (CRCHUM), Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada
⨯
David Possamaï,

Affiliation Research Centre, Centre hospitalier de l′Université de Montréal (CRCHUM), Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada
⨯
Jean-Baptiste Duvignaud,

Affiliations Centre de recherche en infectiologie, Centre hospitalier universitaire de Québec and Department of Microbiology, Infectiology and Immunology, Université Laval, Québec, Québec, Canada, PROTEO, Université Laval, Québec, Québec, Canada
⨯
Denis Leclerc,

Affiliation Centre de recherche en infectiologie, Centre hospitalier universitaire de Québec and Department of Microbiology, Infectiology and Immunology, Université Laval, Québec, Québec, Canada
⨯
Nathalie Grandvaux,

Affiliation Research Centre, Centre hospitalier de l′Université de Montréal (CRCHUM) and Departement of Biochemistry, Université de Montréal, Montréal, Québec, Canada
⨯
Réjean Lapointe

* E-mail: rejean.lapointe@umontreal.ca

Affiliation Research Centre, Centre hospitalier de l′Université de Montréal (CRCHUM), Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada
⨯

Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

Laïla-Aïcha Hanafi,
Dominique Gauchat,
Jessica Godin-Ethier,
David Possamaï,
Jean-Baptiste Duvignaud,
Denis Leclerc,
Nathalie Grandvaux,
Réjean Lapointe

Published: June 9, 2014
https://doi.org/10.1371/journal.pone.0099211

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