Mining of the Pyrrolamide Antibiotics Analogs in Streptomyces netropsis Reveals the Amidohydrolase-Dependent “Iterative Strategy” Underlying the Pyrrole Polymerization

• Chunlin Hao ,

  Contributed equally to this work with: Chunlin Hao, Sheng Huang

  Affiliation Key Laboratory of Combinatory Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China

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• Sheng Huang ,

  Contributed equally to this work with: Chunlin Hao, Sheng Huang

  Affiliation Key Laboratory of Combinatory Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China

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• Zixin Deng,

  Affiliations Key Laboratory of Combinatory Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China, Hubei Engineering Laboratory for Synthetic Microbiology, Wuhan Institute of Biotechnology, Wuhan, China

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• Changming Zhao ,

  * E-mail: cmzhao03@whu.edu.cn (CMZ); yu_yi@whu.edu.cn (YY)

  Affiliation Key Laboratory of Combinatory Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China

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• Yi Yu

  * E-mail: cmzhao03@whu.edu.cn (CMZ); yu_yi@whu.edu.cn (YY)

  Affiliations Key Laboratory of Combinatory Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China, State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

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