Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé Syndrome: A Double-Blind Placebo-Controlled Randomized Split-Face Trial

Lieke M. C. Gijezen; Marigje Vernooij; Herm Martens; Charlene E. U. Oduber; Charles J. M. Henquet; Theo M. Starink; Martin H. Prins; Fred H. Menko; Patty J. Nelemans; Maurice A. M. van Steensel

doi:10.1371/journal.pone.0099071

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Peer-reviewed

Research Article

Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé Syndrome: A Double-Blind Placebo-Controlled Randomized Split-Face Trial

Lieke M. C. Gijezen ,

Contributed equally to this work with: Lieke M. C. Gijezen, Marigje Vernooij

Affiliation Department of Dermatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Marigje Vernooij ,

Contributed equally to this work with: Lieke M. C. Gijezen, Marigje Vernooij

Affiliation Department of Dermatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Herm Martens,

Affiliation Department of Dermatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Charlene E. U. Oduber,

Affiliation Department of Dermatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Charles J. M. Henquet,

Affiliation Department of Dermatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Theo M. Starink,

Affiliation Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands
⨯
Martin H. Prins,

Affiliation Department of Epidemiology, CAPHRI Research School for Public Health Primary Care, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Fred H. Menko,

Affiliation Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
⨯
Patty J. Nelemans,

Affiliation Department of Epidemiology, CAPHRI Research School for Public Health Primary Care, Maastricht University Medical Centre+, Maastricht, The Netherlands
⨯
Maurice A. M. van Steensel

* E-mail: maurice.vansteensel@imb.a-star.sg.edu

Affiliations Department of Dermatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands, Department of Clinical Genetics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands, Institute of Medical Biology, Singapore, Singapore
⨯

Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé Syndrome: A Double-Blind Placebo-Controlled Randomized Split-Face Trial

Lieke M. C. Gijezen,
Marigje Vernooij,
Herm Martens,
Charlene E. U. Oduber,
Charles J. M. Henquet,
Theo M. Starink,
Martin H. Prins,
Fred H. Menko,
Patty J. Nelemans,
Maurice A. M. van Steensel

Published: June 9, 2014
https://doi.org/10.1371/journal.pone.0099071

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