Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

Paula E. Beaumont; Brian McHugh; Emily Gwyer Findlay; Annie Mackellar; Karen J. Mackenzie; Richard L. Gallo; John R. W. Govan; A. John Simpson; Donald J. Davidson

doi:10.1371/journal.pone.0099029

Loading metrics

Open Access

Peer-reviewed

Research Article

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

Paula E. Beaumont,

Affiliation MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Brian McHugh,

Affiliation MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Emily Gwyer Findlay,

Affiliation MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Annie Mackellar,

Affiliation MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Karen J. Mackenzie,

Affiliation MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Richard L. Gallo,

Affiliation Division of Dermatology, Department of Medicine, University of California at San Diego and VA San Diego Health Care System, San Diego, California, United States of America
⨯
John R. W. Govan,

Affiliation Edinburgh Infectious Diseases, The Chancellor's Building, New Royal Infirmary, University of Edinburgh, Edinburgh, Scotland, United Kingdom
⨯
A. John Simpson,

Affiliations MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Donald J. Davidson

* E-mail: donald.davidson@ed.ac.uk

Affiliation MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
⨯

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

Paula E. Beaumont,
Brian McHugh,
Emily Gwyer Findlay,
Annie Mackellar,
Karen J. Mackenzie,
Richard L. Gallo,
John R. W. Govan,
A. John Simpson,
Donald J. Davidson

Published: June 2, 2014
https://doi.org/10.1371/journal.pone.0099029

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neutrophils
Is the Subject Area "Neutrophils" applicable to this article?

Thanks for your feedback.
Pseudomonas aeruginosa
Is the Subject Area "Pseudomonas aeruginosa" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Animal models of infection
Is the Subject Area "Animal models of infection" applicable to this article?

Thanks for your feedback.
Respiratory infections
Is the Subject Area "Respiratory infections" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Pathogens
Is the Subject Area "Pathogens" applicable to this article?

Thanks for your feedback.