Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming

Daniel B. Graham; Douglas G. Osborne; Joshua T. Piotrowski; Timothy S. Gomez; Grzegorz B. Gmyrek; Holly M. Akilesh; Adish Dani; Daniel D. Billadeau; Wojciech Swat

doi:10.1371/journal.pone.0098606

Loading metrics

Open Access

Peer-reviewed

Research Article

Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming

Daniel B. Graham ,

Contributed equally to this work with: Daniel B. Graham, Douglas G. Osborne

Affiliation Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America,
⨯
Douglas G. Osborne ,

Contributed equally to this work with: Daniel B. Graham, Douglas G. Osborne

Affiliation Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Joshua T. Piotrowski,

Affiliation Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Timothy S. Gomez,

Affiliation Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Grzegorz B. Gmyrek,

Affiliation Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America,
⨯
Holly M. Akilesh,

Affiliation Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America,
⨯
Adish Dani,

Affiliation Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America,
⨯
Daniel D. Billadeau ,

* E-mail: swat@wustl.edu (WS); billadeau.daniel@mayo.edu (DDB)

Affiliation Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Wojciech Swat

* E-mail: swat@wustl.edu (WS); billadeau.daniel@mayo.edu (DDB)

Affiliation Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America,
⨯

Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming

Daniel B. Graham,
Douglas G. Osborne,
Joshua T. Piotrowski,
Timothy S. Gomez,
Grzegorz B. Gmyrek,
Holly M. Akilesh,
Adish Dani,
Daniel D. Billadeau,
Wojciech Swat

Published: June 2, 2014
https://doi.org/10.1371/journal.pone.0098606

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Antigen presentation
Is the Subject Area "Antigen presentation" applicable to this article?

Thanks for your feedback.
Lysosomes
Is the Subject Area "Lysosomes" applicable to this article?

Thanks for your feedback.
Cell membranes
Is the Subject Area "Cell membranes" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.
Endosomes
Is the Subject Area "Endosomes" applicable to this article?

Thanks for your feedback.
Endocytosis
Is the Subject Area "Endocytosis" applicable to this article?

Thanks for your feedback.