Chronic Hypoxia Promotes Pulmonary Artery Endothelial Cell Proliferation through H2O2-Induced 5-Lipoxygenase

Open Access

Peer-reviewed

Research Article

Chronic Hypoxia Promotes Pulmonary Artery Endothelial Cell Proliferation through H₂O₂-Induced 5-Lipoxygenase

Kristi M. Porter,

Affiliation Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Department of Pulmonary, Allergy and Critical Care Medicine, Atlanta, Georgia, United States of America
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Bum-Yong Kang,

Affiliation Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Department of Pulmonary, Allergy and Critical Care Medicine, Atlanta, Georgia, United States of America
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Sherry E. Adesina,

Affiliation Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Department of Pulmonary, Allergy and Critical Care Medicine, Atlanta, Georgia, United States of America
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Tamara C. Murphy,

Affiliation Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Department of Pulmonary, Allergy and Critical Care Medicine, Atlanta, Georgia, United States of America
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C. Michael Hart,

Affiliation Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Department of Pulmonary, Allergy and Critical Care Medicine, Atlanta, Georgia, United States of America
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Roy L. Sutliff

* E-mail: rsutlif@emory.edu

Affiliation Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Department of Pulmonary, Allergy and Critical Care Medicine, Atlanta, Georgia, United States of America
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Medical hypoxia
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Endothelial cells
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Pulmonary arteries
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Small interfering RNA
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Cell proliferation
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MTT assay
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Transfection
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Reactive oxygen species
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