Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease

John N. Hutchinson; Towfique Raj; Jes Fagerness; Eli Stahl; Fernando T. Viloria; Alexander Gimelbrant; Johanna Seddon; Mark Daly; Andrew Chess; Robert Plenge

doi:10.1371/journal.pone.0098464

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Open Access

Peer-reviewed

Research Article

Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease

John N. Hutchinson ,

* E-mail: jhutchin@hsph.harvard.edu

Affiliations Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Towfique Raj,

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Jes Fagerness,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Eli Stahl,

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Fernando T. Viloria,

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America
⨯
Alexander Gimelbrant,

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Johanna Seddon,

Affiliations Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, Boston, Massachusetts, United States of America
⨯
Mark Daly,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Andrew Chess,

Affiliation Department of Developmental and Regenerative Biology, Fishberg Department of Neuroscience, Department of Genetics and Genomic Sciences, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Robert Plenge

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯

Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease

John N. Hutchinson,
Towfique Raj,
Jes Fagerness,
Eli Stahl,
Fernando T. Viloria,
Alexander Gimelbrant,
Johanna Seddon,
Mark Daly,
Andrew Chess,
Robert Plenge

Published: June 9, 2014
https://doi.org/10.1371/journal.pone.0098464

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DNA methylation
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Methylation
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Single nucleotide polymorphisms
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Microarrays
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Genome-wide association studies
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Heterozygosity
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Alleles
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Genomics
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