SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

Rogier van Gent; Claudio Di Sanza; Niels J. F. van den Broek; Veerle Fleskens; Aukje Veenstra; Gerdine J. Stout; Arjan B. Brenkman

doi:10.1371/journal.pone.0098438

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Peer-reviewed

Research Article

SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

Rogier van Gent ,

Contributed equally to this work with: Rogier van Gent, Claudio Di Sanza

Affiliations Center for Molecular Medicine, Department of Molecular Cancer Research, Section Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands, and Netherlands Metabolomics Centre, Leiden, The Netherlands, Erasmus Medical Center Rotterdam, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
⨯
Claudio Di Sanza ,

Contributed equally to this work with: Rogier van Gent, Claudio Di Sanza

Affiliation Center for Molecular Medicine, Department of Molecular Cancer Research, Section Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands, and Netherlands Metabolomics Centre, Leiden, The Netherlands
⨯
Niels J. F. van den Broek,

Affiliation Center for Molecular Medicine, Department of Molecular Cancer Research, Section Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands, and Netherlands Metabolomics Centre, Leiden, The Netherlands
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Veerle Fleskens,

Affiliation University Medical Center Utrecht, Department of Cell Biology, Utrecht, The Netherlands
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Aukje Veenstra,

Affiliation Center for Molecular Medicine, Department of Molecular Cancer Research, Section Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands, and Netherlands Metabolomics Centre, Leiden, The Netherlands
⨯
Gerdine J. Stout,

Affiliation Center for Molecular Medicine, Department of Molecular Cancer Research, Section Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands, and Netherlands Metabolomics Centre, Leiden, The Netherlands
⨯
Arjan B. Brenkman

* E-mail: a.b.brenkman@umcutrecht.nl

Affiliation Center for Molecular Medicine, Department of Molecular Cancer Research, Section Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands, and Netherlands Metabolomics Centre, Leiden, The Netherlands
⨯

SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner

Rogier van Gent,
Claudio Di Sanza,
Niels J. F. van den Broek,
Veerle Fleskens,
Aukje Veenstra,
Gerdine J. Stout,
Arjan B. Brenkman

Published: May 29, 2014
https://doi.org/10.1371/journal.pone.0098438

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