Expression of PD-L1 on Canine Tumor Cells and Enhancement of IFN-γ Production from Tumor-Infiltrating Cells by PD-L1 Blockade

Naoya Maekawa; Satoru Konnai; Ryoyo Ikebuchi; Tomohiro Okagawa; Mami Adachi; Satoshi Takagi; Yumiko Kagawa; Chie Nakajima; Yasuhiko Suzuki; Shiro Murata; Kazuhiko Ohashi

doi:10.1371/journal.pone.0098415

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Open Access

Peer-reviewed

Research Article

Expression of PD-L1 on Canine Tumor Cells and Enhancement of IFN-γ Production from Tumor-Infiltrating Cells by PD-L1 Blockade

Naoya Maekawa,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Satoru Konnai,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Ryoyo Ikebuchi,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Tomohiro Okagawa,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Mami Adachi,

Affiliation Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Satoshi Takagi,

Affiliation Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Yumiko Kagawa,

Affiliations Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, North Lab, Sapporo, Japan
⨯
Chie Nakajima,

Affiliation Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
⨯
Yasuhiko Suzuki,

Affiliation Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
⨯
Shiro Murata,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Kazuhiko Ohashi

* E-mail: okazu@vetmed.hokudai.ac.jp

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯

Expression of PD-L1 on Canine Tumor Cells and Enhancement of IFN-γ Production from Tumor-Infiltrating Cells by PD-L1 Blockade

Naoya Maekawa,
Satoru Konnai,
Ryoyo Ikebuchi,
Tomohiro Okagawa,
Mami Adachi,
Satoshi Takagi,
Yumiko Kagawa,
Chie Nakajima,
Yasuhiko Suzuki,
Shiro Murata

Published: June 10, 2014
https://doi.org/10.1371/journal.pone.0098415

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