A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum

• Hazrat Ali ,

  Contributed equally to this work with: Hazrat Ali, Marco I. Ries

  Current address: Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan

  Affiliations Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentations, Delft, The Netherlands

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• Marco I. Ries ,

  Contributed equally to this work with: Hazrat Ali, Marco I. Ries

  Affiliation Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands

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• Peter P. Lankhorst,

  Affiliation DSM Biotechnology Center, Delft, The Netherlands

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• Rob A. M. van der Hoeven,

  Affiliation DSM Biotechnology Center, Delft, The Netherlands

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• Olaf L. Schouten,

  Affiliation DSM Biotechnology Center, Delft, The Netherlands

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• Marek Noga,

  Affiliations Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands

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• Thomas Hankemeier,

  Affiliations Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands

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• Noël N. M. E. van Peij,

  Affiliation DSM Biotechnology Center, Delft, The Netherlands

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• Roel A. L. Bovenberg,

  Affiliations DSM Biotechnology Center, Delft, The Netherlands, Synthetic Biology and Cell Engineering, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

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• Rob J. Vreeken,

  Affiliations Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands

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• Arnold J. M. Driessen

  * E-mail: a.j.m.driessen@rug.nl

  Affiliations Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands, Kluyver Centre for Genomics of Industrial Fermentations, Delft, The Netherlands

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